MATERIAL PROFILE / Individual substance
CAS: 6920-22-5
Function: Cosmetic solvent, skin-conditioning and moisturizing ingredient; product-protection enhancer
Compare this material →Reviewed by Dave · 2026-11-02
Scope: Chemical identity, supplied Wako SDS and specification matches, sourced technical-property transcription and conditions, and the reviewed application and grade-specific sustainability context.
Owner explicitly approved the reviewed record for publication. Core data coverage remains 15/16; melting point and manufacturing origin remain unverified. Green certifications remain supplier claims, not independently validated certifications. Neutral remains a provisional owner-assigned category; this mark is not a safety or regulatory approval.
1,2-Hexanediol is a diol with adjacent hydroxyl groups. Supplier-described cosmetic functions include moisturizing, solubilizing and product-protection enhancement. Skin-care and hair-care applications depend on the grade and finished formulation. The supplied FUJIFILM Wako reagent is for research use only, separate from cosmetic supplier grades.
Chemistry: Six-carbon vicinal diol · C6H14O2
Listed supplier: Multiple suppliers · individual chemical
Chemical identity only; purity, grade and supplier composition require separate documentation.
Identity snapshot: 2026-11-02 UTC.
CAS identity reference ↗Provisional · assigned by Dave · November 2, 2026
Owner-assigned category pending a documented assessment. It is separate from human verification, certification and a numerical score. Neutral does not establish safety in every use or verified renewable origin.
Cosmetics and personal care are the main documented application context here. COSMILE Europe lists skin-conditioning and solvent functions. Symrise describes moisturizing, solubilizing, sensory and emulsion-stabilizing benefits for its named grade, alongside support for product protection.
Supplier examples include creams, lotions, serums and gels, plus shampoos, conditioners and leave-in treatments. Moisturizing and preservative-enhancing claims are formulation-dependent. Product-protection support does not establish that an ingredient alone is an authorized preservative or a complete preservation system; verify finished-product microbial performance.
Cosmetic ingredient functions ↗ · Symrise applications ↗ · Cozmat grade applications ↗
The supplied market reports give substantially different estimates. Comparable scope and production data have not been established, so no market value, market share or growth forecast is adopted. Food-preservative authorization, drug-formulation suitability and claimed leadership of named manufacturers have not been confirmed. Research reagent availability does not establish a pharmaceutical, food or cosmetic grade.
FUJIFILM Wako 1,2-Hexanediol · code 085-07432 · supplier-listed 25 mL package. The specification gives assay ≥96.0% by capillary GC and specific optical rotation −0.3 to +0.3° at 20 °C, sodium D line, neat.
Specification revision: May 29, 2023. The separate printed header reads November 3, 2026, one day after this review; it is not substituted for the revision date. These are grade limits, not lot-specific test results. The SDS recommends research use only.
The supplied Wako SDS, revision 2.04 issued February 26, 2026, classifies the reagent as eye irritation Category 2A, with Warning and H319. Avoid eye exposure and use the protective equipment, ventilation and first-aid measures specified in the complete SDS.
A published 2012 CIR assessment concluded that the reviewed 1,2-glycols, including 1,2-hexanediol, were safe under the cosmetic uses and concentrations evaluated in that report. It also discussed penetration enhancement and the effect on other formula ingredients. This historical assessment does not establish that every concentration, raw reagent or finished formulation is safe, or that it cannot cause individual reactions.
Published CIR safety assessment and its scope ↗ · Full research-grade SDS ↗
Keep tightly closed, protected from light and in a well-ventilated place at room temperature, preferably cool. Avoid strong oxidizers, ignition sources and temperature extremes. The SDS reports transport as not regulated under ADR/RID, IMDG and IATA; this is separate from eye-irritation hazards.
The supplied SDS provides no ecological toxicity, persistence/degradation or bioaccumulation data. It also leaves melting point and viscosity unreported. Missing data are not proof of absence of risk.
The chemical name alone does not establish renewable sourcing or a lower environmental footprint. Symrise describes Hydrolite® 6 green as based on sustainably sourced raw materials. Cozmat states that Hanaco® Hexiol Green has 100% biobased carbon by ASTM D6866 and COSMOS Approved status. These are supplier statements for named offerings; current certificates and scope still require review.
Biobased carbon is a feedstock measure, not proof of harmlessness, ready biodegradability or a lower lifecycle footprint. No bio-based or eco-certification claim is transferred to the Wako reagent.
SymDiol® 68 green combines 1,2-hexanediol with caprylyl glycol. It is a blend, not another name for the single-substance record on this page. Its composition, technical properties and certifications must be checked separately.
Symrise blend description ↗Dave approved this record on November 2, 2026. The human-verification mark covers the stated information and document matches; missing fields, supplier claims and the provisional EcoSafe category retain their qualifications.
15 of 16 defined fields are recorded with a source. This measures structured information currently on this site, not the completeness of every linked PDF. Missing fields remain in the denominator.
Coverage is separate from scientific accuracy, human verification and EcoSafe assessment. Molecular fields may not apply to a grade or family; they are not filled from another material to increase its score.
| Core field | Recorded information |
|---|---|
| Chemical name | 1,2-Hexanediol Source ↗ |
| CAS number | 6920-22-5 Source ↗ |
| Synonyms | Hexane-1,2-diol; 1,2-dihydroxyhexane; DL-1,2-hexanediol Source ↗ |
| Molecular formula | C6H14O2 Source ↗ |
| Molecular weight | 118.17 Source ↗ |
| IUPAC name | hexane-1,2-diol Source ↗ |
| PubChem CID | 94335 Source ↗ |
| Identity sources | https://pubchem.ncbi.nlm.nih.gov/compound/94335 Source ↗ Source reference recorded for this record's scope; source freshness is a separate review. |
| Uses | Cosmetic solvent, skin conditioning and moisturizing; supplier-described product-protection enhancement Source ↗ Finished-product efficacy and use conditions require formulation-specific assessment; Wako grade is research-only. |
| Hazards | Warning; H319 causes serious eye irritation; Category 2A (Japan JIS supplier classification) Source ↗ Classification of the supplied research reagent, not a determination for all finished cosmetic formulations. |
| Appearance | Colorless to nearly colorless, clear liquid Source ↗ |
| Density | 0.953 g/mL Source ↗ 20 °C; SDS labels relative density but supplies mass/volume units · Method not stated · Substance reference |
| Melting point | Not yet recorded / may not apply |
| Boiling point | 223–224 °C Source ↗ Pressure not stated · Method not stated · Substance reference |
| Solubility | Very soluble in water, ethanol and acetone Source ↗ Temperature not stated · Qualitative SDS description · Substance reference |
| SDS/TDS | 1,2-Hexanediol — FUJIFILM Wako SDS Source ↗ Complete six-page user-supplied SDS. CAS 6920-22-5; code 085-07432. Research use only. Does not characterize every cosmetic grade. |
Trade names identify supplier offerings. A shared chemical name does not establish interchangeable grades or specifications.
Supplier-described sustainably sourced cosmetic grade. Its green claims do not characterize Wako reagent or every product sharing this CAS.
Supplier states natural origin, 100% biobased carbon by ASTM D6866 and COSMOS Approved. Current certification scope and certificate have not been independently checked.
FUJIFILM Wako 1,2-Hexanediol, code 085-07432; CAS 6920-22-5. Research reagent grade. Specification limits are separate from SDS reference values and cosmetic-grade claims. Not a batch certificate of analysis. Melting point, viscosity and water specification are not reported in the supplied PDFs.
| Property | Value | Conditions / method |
|---|---|---|
| Specific optical rotation | −0.3 to +0.3 ° Specification | [α]D20; neat Polarimetry; further method not stated Source ↗ |
| Solubility | Very soluble in water, ethanol and acetone Substance reference | Temperature not stated Qualitative SDS description Source ↗ |
| Boiling point | 223–224 °C Substance reference | Pressure not stated Method not stated Source ↗ |
| Density | 0.953 g/mL Substance reference | 20 °C; SDS labels relative density but supplies mass/volume units Method not stated Source ↗ |
| Purity / assay | ≥96.0 % Specification | Assay; percentage basis not further specified Capillary gas chromatography Source ↗ |
| Flash point | 122 °C Substance reference | Open/closed cup not stated Method not stated Source ↗ |
Archived copies are dated references. Confirm the latest document for your supplier, grade and region.
SDS · FUJIFILM Wako
Revision 2.04 · issued February 26, 2026 · Japan JIS Z 7253:2019 · English
Complete six-page user-supplied SDS. CAS 6920-22-5; code 085-07432. Research use only. Does not characterize every cosmetic grade.
Open archived copy ↗ · Download · Supplier source ↗TDS · FUJIFILM Wako
Revised May 29, 2023; separate printed header November 3, 2026 · English · code 08-0743
One-page specification: appearance, assay and optical rotation. A technical specification, not a lot-specific CoA. Header is later than this review and is not treated as the revision date.
Open archived copy ↗ · Download · Supplier source ↗Technical reference · Cosmetic Ingredient Review / International Journal of Toxicology
Published 2012 · DOI 10.1177/1091581812460409 · Cosmetic-use assessment; scope and use conditions in report
Published group assessment includes 1,2-hexanediol. Historical safety context, not a current supplier SDS, blanket approval or evidence for all concentrations.
Supplier access / request ↗Identity data and category placement do not establish safety, suitability or environmental performance. Obtain current grade-specific documentation.
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Library source check: November 2, 2026. Sources may require supplier access.